反应详情

温度

70 °C

Mixture of tert-butyl 3-iodoazetidine-1-carboxylate (STEP B, 2.05 g, 7.24 mmol), cesium carbonate (4.72 g, 14.5 mmol), thioacetic acid (1.10 g, 14.5 mmol) and dimethyl formamide (10 mL) was stirred at 70° C. for 4 h. The reaction mixture was cooled to room temperature and diluted with diethyl ether (200 mL). The resulting mixture was washed with water (80 mL×3) and brine (50 mL), then dried over magnesium sulfate.

1. temperatureThe reaction mixture was cooled to room temperature
2. washThe resulting mixture was washed with water (80 mL×3) and brine (50 mL)
3. dry with materialdried over magnesium sulfate