Potassium Carbonate → HCID 22568978, compound

HRID 24164Notes

Reaction equation

HRID 24164 reaction equation
COC(=O)CC1C=CC([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3([O:22][CH2:23][C:24]4C=CC=CC=4)[CH2:21][CH2:20]3)=[C:15]([CH3:30])[CH:14]=2)=CC=1.[C:32](=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([O:22][CH:23]([CH3:24])[CH3:32])[CH2:20][CH2:21]2)=[C:15]([CH3:30])[CH:14]=1)#[CH:11]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86585924Methyl{4-[4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-phenyl}-acetate2×

Product 1

HCID 22568978HCID 22568978, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 80, 250.0 mg, 0.87 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (180 mg, 98%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-39ee4dab9caa4960a5a463e8d12d8ada
Source dataset
uspto-grants-2005_02
Patent number
US06855512B2

Reaction notes

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