Methylamine → HCID 69732790, compound

Participants

Reaction Steps

A mixture of (R)-3-(5-acetoxyhexyl)-1,7-dimethyl-5-trifluoromethanesulfonyloxypyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (30 mg, 0.062 mmol), methanol (1 ml), and 40% aqueous methylamine (1 ml) was stirred at room temperature for 10 minutes. Concentration under reduced pressure provided crude (R)-3-(5-acetoxyhexyl)-1,7-dimethyl-5-(N-methylamino)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione which was used immediately in the next step.

Provenance & Evidence