Methylamine → HCID 69732790, compound

HRID 2416419Notes

Reaction equation

HRID 2416419 reaction equation
[C:1]([O:4][C@H:5]([CH3:32])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:15](=[O:16])[C:14]2[C:17](OS(C(F)(F)F)(=O)=O)=[CH:18][C:19]([CH3:21])=[N:20][C:13]=2[N:12]([CH3:30])[C:11]1=[O:31])(=[O:3])[CH3:2].[CH3:33][NH2:34]>CO>[C:1]([O:4][C@H:5]([CH3:32])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:15](=[O:16])[C:14]2[C:17]([NH:34][CH3:33])=[CH:18][C:19]([CH3:21])=[N:20][C:13]=2[N:12]([CH3:30])[C:11]1=[O:31])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86590998HCID 86590998, compound

Product 1

HCID 69732790HCID 69732790, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (R)-3-(5-acetoxyhexyl)-1,7-dimethyl-5-trifluoromethanesulfonyloxypyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (30 mg, 0.062 mmol), methanol (1 ml), and 40% aqueous methylamine (1 ml) was stirred at room temperature for 10 minutes. Concentration under reduced pressure provided crude (R)-3-(5-acetoxyhexyl)-1,7-dimethyl-5-(N-methylamino)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione which was used immediately in the next step.

Workup

  1. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-458f50a2f217477dbe56235de57f2f41
Source dataset
uspto-grants-2004_11
Patent number
US06825180B2

Reaction notes

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