反应详情

To a solution of (4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)-1-tritylpiperidine-4-yl)methanol (STEP F, 300 mg, 0.453 mmol) in dichloromethane (6 mL) was trifluoroacetic acid (2 mL). After 20 min, the mixture was concentrated in vacuo and the residue was diluted with methanol and the solution was filtered through strong cationic exchange column (SCX). The column was washed with 1 mol/L ammonia methanol to wash out the product. The filtrate was concentrated in vacuo to give the title compound (200 mg, quantitative yield).

1. concentrationthe mixture was concentrated in vacuo
2. additionthe residue was diluted with methanol
3. filtrationthe solution was filtered through strong cationic exchange column (SCX)
4. washThe column was washed with 1 mol/L ammonia methanol
5. washto wash out the product
6. concentrationThe filtrate was concentrated in vacuo