Acetyl chloride → 1-(4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)-4-(hydroxymethyl)piperidin-1-yl)ethanone

HRID 241650Notes

Reaction equation

HRID 241650 reaction equation
[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([S:14]([C:17]4([CH2:23][OH:24])[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)(=[O:16])=[O:15])=[CH:13][C:8]=3[N:7]=[C:6]2[CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])[CH2:3][CH2:2]1.[C:30](Cl)(=[O:32])[CH3:31]>>[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([S:14]([C:17]4([CH2:23][OH:24])[CH2:22][CH2:21][N:20]([C:30](=[O:32])[CH3:31])[CH2:19][CH2:18]4)(=[O:16])=[O:15])=[CH:13][C:8]=3[N:7]=[C:6]2[CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 58513575(4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)piperidin-4-yl)methanol

Product 1

HCID 468518841-(4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)-4-(hydroxymethyl)piperidin-1-yl)ethanone

Procedure

The title compound was prepared according to the procedure described in STEP D of Example 6 using (4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)piperidin-4-yl)methanol (STEP G) and acetyl chloride instead of methanesulfonyl chloride.

Sources & evidence

ORD record
ord-dfcae91e1c794cffacb6fb9e06f70a39
Source dataset
uspto-grants-2014_02
Patent number
US08653063B2

Reaction notes

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