Chloropyrazine → 5-Pyrazinyl-3-thiophenecarboxaldehyde

HRID 2416523Notes

Reaction equation

Br[C:2]1[S:6][CH:5]=[C:4]([CH:7]=[O:8])[CH:3]=1.Cl[C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1.BrC1C=CC(C=O)=C(F)C=1.BrC1N=CC=CN=1>>[N:11]1[CH:12]=[CH:13][N:14]=[CH:15][C:10]=1[C:2]1[S:6][CH:5]=[C:4]([CH:7]=[O:8])[CH:3]=1

Participants

Reactant 4

HCID 73277Chloropyrazine

HCID 783452-Bromopyrimidine

HCID 1435174-Bromo-2-fluorobenzaldehyde

HCID 122848945-Bromothiophene-3-carbaldehyde

Product 1

HCID 865902755-Pyrazinyl-3-thiophenecarboxaldehyde

Procedure

The title compound is prepared by a procedure analogous to Reference Example 15 by substituting 5-bromo-3-thiophenecarboxaldehyde (prepared as described in Chem. Pharm. Bull. 1999, 47,1393) and chloropyrazine, respectively, for the 4-bromo-2-fluorobenzaldehyde and 2-bromopyrimidine of Reference Example 15. MS 191 (M+H)+.

Sources & evidence

ORD record: ord-f128ac031bf14c27890b8e8ff2981759
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06825170B2

Reaction notes

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