Benzylamine → HCID 22631323, compound

HRID 2416590Notes

Reaction equation

HRID 2416590 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([I:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>ClCCl>[CH2:15]([NH:22][C:2]1[C:11]2[C:6](=[CH:7][C:8]([I:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[CH:4][N:3]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 22631339HCID 22631339, compound

Product 1

HCID 22631323HCID 22631323, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
140 °C

Procedure

2.82 g (8.86 mmol) of 1-chloro-6-iodo-7-methoxyisoquinoline was added to 15 ml of benzylamine, and they were stirred at 140° C. overnight. After the treatment with dichloromethane as the extraction solvent in an ordinary manner, the obtained crude product was purified by the silica gel column chromatography to obtain the title compound.

Workup

  1. customwas purified by the silica gel column chromatography

Sources & evidence

ORD record
ord-e9b88924dfd04336a8deecb520be824f
Source dataset
uspto-grants-2004_11
Patent number
US06825181B1

Reaction notes

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