Sodium Acetate → HCID 22632742, compound

HRID 2416617Notes

Reaction equation

HRID 2416617 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[C:7]([C:9]2[O:10][CH2:11][C:12](=[O:21])[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=2)[CH:6]=[CH:5][N:4]=1.C([O-])(=O)C.[Na+]>CO.[Pd]>[ClH:2].[N:4]1[CH:5]=[CH:6][C:7]([C:9]2[O:10][CH2:11][C:12](=[O:21])[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=2)=[CH:8][CH:3]=1

Participants

5

Reactant 2

HCID 517045Sodium AcetateHCID 22632740HCID 22632740, compound

Product 1

HCID 22632742HCID 22632742, compoundYield 33.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(2-Chloro-4-pyridyl)-4-phenyl-4H-1,3,4-oxadiazine-5(6H)-one hydrochloride (780 mg, 2.4 mmol) obtained in Example 12 was hydrogenated in a usual manner in methanol in the presence of sodium acetate and 10% palladium/carbon catalyst, to give the title compound (230 mg, yield 33%).

Sources & evidence

ORD record
ord-94d7cc01c10341d0927b3bd4f2a59b8c
Source dataset
uspto-grants-2004_11
Patent number
US06825192B1

Reaction notes

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