N-methyl-2-pyrrolidone → HCID 22632787, compound

Participants

Reaction Steps

2-(2-Pyridyl)-4-(2-iodophenyl)-4H-1,3,4-oxadiazine-5(6H)-one (100 mg) obtained in Example 105 was dissolved in N-methyl pyrrolidone (2 ml). Zinc cyanide (80 mg), copper iodide (5 mg) and tetrakis(triphenyl phosphine) palladium (10 mg) were added thereto, followed by stirring for 1 hour. The reaction solution was diluted with an aqueous saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. After the drying agent was filtered off, the reaction solution was evaporated and purified by silica gel chromatography (hexane/ethyl acetate system), to give the title compound (40 mg, 54%).

Provenance & Evidence