HCID 54264421, compound → HCID 54445606, compound

HRID 2416682Notes

Reaction equation

HRID 2416682 reaction equation
[C:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[CH2:20][N:21](C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)[CH2:6][C:7]([O:9][CH3:10])=[O:8])([O:3][CH3:4])=[O:2]>C(Cl)(Cl)Cl.FC(F)(F)C(O)=O>[C:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[CH2:20][NH2:21])[CH2:6][C:7]([O:9][CH3:10])=[O:8])([O:3][CH3:4])=[O:2]

Participants

4

Reactant 1

HCID 54264421HCID 54264421, compound

Product 1

HCID 54445606HCID 54445606, compoundYield 139.8%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of methyl (±)-3-carbomethoxy-4-[2-bis(tert-butoxycarbonyl)aminomethyl-4-methoxyphenyl]butanoate (12 g) in chloroform (100 mL) and trifluoroacetic acid (50 mL) was stirred under argon at room temperature for 4 hr. The solution was then concentrated under vacuum to give the title compound (10 g, 100%) as a viscous oil: MS (ES) m/e 296.2 (M+H)+.

Workup

  1. concentrationThe solution was then concentrated under vacuum

Sources & evidence

ORD record
ord-3f7ea30bdb3d4c9ea1f6b851e7b950fc
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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