1,4-Dioxane hydrochloride → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate

HRID 2416693Notes

Reaction equation

HRID 2416693 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][CH2:13]C(OC(C)(C)C)=O)[N:7]=1)[CH3:2].Cl.O1CCOCC1>>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][CH3:13])[N:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22496030Ethyl-6-[(tert-butoxycarbonyl)methylamino]-2-pyridylacetate

Product 1

HCID 22507068Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate

Procedure

A solution of ethyl-6-[(tert-butoxycarbonyl)methylamino]-2-pyridylacetate (0.6 g, 2 mmol) and 4 M HCl/dioxane (5 mL, 20 mmol) was stirred at RT overnight, then was concentrated. Reconcentration from toluene gave the title compound as white solid: MS (ES) m/e 195 (M+H)+.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-7ad9f5869d8f44f5b20c20eadcc6b005
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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