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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2416693Generated: October 31, 2026

1,4-Dioxane hydrochloride → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate

https://huagongshe.com/reaction/2416693

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
ReactantEthyl-6-[(tert-butoxycarbonyl)methylamino]-2-pyridylacetateHCID 22496030—
ProductEthyl 2-(6-(methylamino)pyridin-2-yl)acetateHCID 22507068—

Reaction Steps

A solution of ethyl-6-[(tert-butoxycarbonyl)methylamino]-2-pyridylacetate (0.6 g, 2 mmol) and 4 M HCl/dioxane (5 mL, 20 mmol) was stirred at RT overnight, then was concentrated. Reconcentration from toluene gave the title compound as white solid: MS (ES) m/e 195 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06825188B2
Source datasetuspto-grants-2004_11
ORD IDord-7ad9f5869d8f44f5b20c20eadcc6b005
Source noteuspto-grants-2004_11