Trifluoroacetic acid → HCID 131724662, compound

HRID 2416716Notes

Reaction equation

HRID 2416716 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:29]=[CH:28][C:16]2[CH2:17][CH:18]([CH2:23][C:24]([O:26][CH3:27])=[O:25])[C:19](=[O:22])[NH:20][CH2:21][C:15]=2[CH:14]=1)=O)(C)(C)C.[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>C(Cl)Cl>[F:33][C:32]([F:35])([F:34])[C:30]([OH:36])=[O:31].[NH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:29]=[CH:28][C:16]2[CH2:17][CH:18]([CH2:23][C:24]([O:26][CH3:27])=[O:25])[C:19](=[O:22])[NH:20][CH2:21][C:15]=2[CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54427559HCID 54427559, compound

Product 1

HCID 131724662HCID 131724662, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of methyl (±)-8-[3-(tert-butoxycarbonylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate (0.70 g) in CH2Cl2 (7 mL) and TFA (2 mL) was stirred under argon at 0° C. for 1 hr, then was concentrated to give the title compound (0.75 g, 100%) as a colorless glass: MS (ES) m/e 321.4 (M+H)+.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-f3241258f5bd4ff08890b93066743cc2
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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