HCID 53957185, compound → HCID 22632202, compound

HRID 2416729Notes

Reaction equation

HRID 2416729 reaction equation
[O:1]=[C:2]1[CH:8]([CH2:9][C:10]([O:12]C)=[O:11])[CH2:7][C:6]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[CH:17][C:5]=2[CH2:4][N:3]1[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][CH:38]=1.N1C=CC=CC=1NCCCOC1C=CC2CC(CC(OCC)=O)C(=O)NCC=2C=1>O>[O:1]=[C:2]1[CH:8]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][C:6]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[CH:17][C:5]=2[CH2:4][N:3]1[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:44])[F:45])=[CH:39][CH:38]=1

Participants

4

Reactant 2

HCID 53957185HCID 53957185, compoundHCID 54434818HCID 54434818, compound

Product 1

HCID 22632202HCID 22632202, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 1(c), except substituting methyl (±)-3-oxo8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate for the ethyl (±)-8-[3-(2-pyridylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the title compound was prepared as an off-white solid: MS (ES) m/e 628.4 (M+H)+. Anal. Calcd for C33H36F3N3O6.0.5 H2O: C, 62.25; H, 5.86; N, 6.60. Found C, 62.01; H, 5.92; N, 6.81.

Sources & evidence

ORD record
ord-070de8f0a2394d0b85197f60d015506d
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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