Trifluoroacetic acid → HCID 22632258, compound

HRID 2416732Notes

Reaction equation

HRID 2416732 reaction equation
[CH2:1]([N:8]1[C:14](=[O:15])[CH:13]([CH2:16][C:17]([OH:19])=[O:18])[CH2:12][C:11]2[CH:20]=[CH:21][C:22]([O:24][CH2:25][CH2:26][CH2:27][N:28]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=3)C(OC(C)(C)C)=O)=[CH:23][C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=C1C(CC(O)=O)CC2C=CC(OCCCN(C3C=CC=CN=3)C(OC(C)(C)C)=O)=CC=2CN1CC1C=CC(C(F)(F)F)=CC=1.C(C(O)=O)(F)(F)F>O>[CH2:1]([N:8]1[C:14](=[O:15])[CH:13]([CH2:16][C:17]([OH:19])=[O:18])[CH2:12][C:11]2[CH:20]=[CH:21][C:22]([O:24][CH2:25][CH2:26][CH2:27][NH:28][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=3)=[CH:23][C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 22632202HCID 22632202, compoundHCID 22632286HCID 22632286, compound

Product 1

HCID 22632258HCID 22632258, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 25(a) except substituting (±)-2-benzyl-3-oxo-8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid for the (±)-3-oxo-8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid, the title compound (0.014 g, 40%) was prepared: MS (ES) m/e 460.4 (M+H)+. Anal. Calcd for C27H29N3O4.CF3CO2H.2 H2O: C, 57.14; H, 5.62; N, 6.89. Found: C, 57.44; H, 5.32; N, 6.87.

Sources & evidence

ORD record
ord-b4b32b6c932f41ceb5c3b701c9695c0e
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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