HCID 54434818, compound → HCID 22632139, compound

HRID 2416733Notes

Reaction equation

HRID 2416733 reaction equation
[C:1]([CH2:4][N:5]1[C:11](=[O:12])[CH:10]([CH2:13][C:14]([O:16]C)=[O:15])[CH2:9][C:8]2[CH:18]=[CH:19][C:20]([O:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)=[CH:21][C:7]=2[CH2:6]1)([OH:3])=[O:2].N1C=CC=CC=1NCCCOC1C=CC2CC(CC(OCC)=O)C(=O)NCC=2C=1>O>[C:1]([CH2:4][N:5]1[C:11](=[O:12])[CH:10]([CH2:13][C:14]([OH:16])=[O:15])[CH2:9][C:8]2[CH:18]=[CH:19][C:20]([O:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)=[CH:21][C:7]=2[CH2:6]1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 54434818HCID 54434818, compoundHCID 54526853HCID 54526853, compound

Product 1

HCID 22632139HCID 22632139, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 1(c) except substituting methyl (±)-2-(carboxymethyl)-3-oxo-8-[3-(pyridin-2-ylamino)-1-propyloxy]-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate for the ethyl (±)-8-[3-(2-pyridylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the title compound (0.30 g, 56%) was prepared: MS (ES) m/e 428.4 (M+H)+. Anal. Calcd for C22H25N3O6.2 H2O: C, 57.01; H, 6.31; N, 9.07; Found: C, 57.27; H, 6.24; N, 8.86.

Sources & evidence

ORD record
ord-6dfc408aba8f42cbafc4059f9ddd0b45
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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