Trifluoroacetic acid → HCID 22632127, compound

HRID 2416734Notes

Reaction equation

HRID 2416734 reaction equation
[N:1]1C=CC=CC=1N(CCCOC1C(CC(O)=O)CC2C=CC=CC=2CN1)C(OC(C)(C)C)=O.[O:34]=[C:35]1[CH:41]([CH2:42][C:43]([OH:45])=[O:44])[CH2:40][C:39]2[CH:46]=[CH:47][C:48]([O:50][CH2:51][CH2:52][CH2:53][N:54]([C:62]3[CH:67]=[CH:66][CH:65]=[CH:64][N:63]=3)C(OC(C)(C)C)=O)=[CH:49][C:38]=2[CH2:37][N:36]1[CH2:68][C:69]1[CH:74]=[CH:73][C:72](C(F)(F)F)=[CH:71][CH:70]=1.C(C(O)=O)(F)(F)F>O>[NH2:1][C:72]1[CH:73]=[CH:74][C:69]([CH2:68][N:36]2[C:35](=[O:34])[CH:41]([CH2:42][C:43]([OH:45])=[O:44])[CH2:40][C:39]3[CH:46]=[CH:47][C:48]([O:50][CH2:51][CH2:52][CH2:53][NH:54][C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][N:63]=4)=[CH:49][C:38]=3[CH2:37]2)=[CH:70][CH:71]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 22632202HCID 22632202, compoundHCID 86591933HCID 86591933, compound

Product 1

HCID 22632127HCID 22632127, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 25(a) except substituting (±)-2-(4-aminobenzyl)-3-oxo-[3-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid for the (±)-3-oxo-8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2-(4-triflouromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid, the title compound (0.029 g, 44%) was prepared: MS (ES) m/e 475.4 (M+H)+. Anal. Calcd for C27H30N4O4.2 CF3CO2H.1.5 H2O: C, 51.03; H, 4.83; N, 7.68. Found: C, 50.92; H, 4.78; N, 7.64.

Sources & evidence

ORD record
ord-20c40e5645de4d578156fd469681af2d
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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