HCID 53957185, compound → HCID 57459730, compound

HRID 2416736Notes

Reaction equation

HRID 2416736 reaction equation
[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([O:12]C)=[O:11])[CH2:7][C:6]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[CH:17][C:5]=2[CH2:4][N:3]1[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][CH:38]=1.O=C1C(CC(OC)=O)CC2C=CC(OCCCN(C3C=CC=CN=3)C(OC(C)(C)C)=O)=CC=2CN1CC1C=CC(C(F)(F)F)=CC=1>>[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][C:6]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[CH:17][C:5]=2[CH2:4][N:3]1[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:44])[F:45])=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 53957185HCID 53957185, compoundHCID 86591934HCID 86591934, compound

Product 1

HCID 57459730HCID 57459730, compoundYield 60%

Procedure

According to the procedure of Example 24(c) except substituting methyl (S)-3-oxo-8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate for the methyl (±)-3-oxo-8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the title compound (0.8 g, 60%) was prepared: MS (ES) m/e 628.1 (M+H)+.

Sources & evidence

ORD record
ord-869a6d74e17b47afa6cc3c0b83d2b7a8
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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