HCID 15908876, compound → HCID 15908877, compound

HRID 2416769Notes

Reaction equation

HRID 2416769 reaction equation
C([O:8][N:9]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][C:14]([F:21])=[C:15]([F:20])[CH:16]=2)[N:11]([CH2:22][CH3:23])[C:10]1=[O:24])C1C=CC=CC=1.[H][H]>C1COCC1.CO.[Pd]>[CH2:22]([N:11]1[C:12]2[C:17](=[CH:16][C:15]([F:20])=[C:14]([F:21])[CH:13]=2)[C:18](=[O:19])[N:9]([OH:8])[C:10]1=[O:24])[CH3:23]

Participants

6

Reactant 2

HCID 15908876HCID 15908876, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15908877HCID 15908877, compoundYield 77.4%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Twenty percent Pd/C was added to a solution of 3-benzyloxy-1-ethyl-6,7-difluoro-1H-quinazoline-2,4-dione (Example C, 0.055 g, 0.16 mmol) in 25 mL of THF and 25 mL of methanol. This was shaken under 50 PSI of hydrogen for 12.5 hours. The mixture was filtered and concentrated to afford 0.03 g of the title compound as a solid, mp 172-174° C.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-da9fd4bf025640ca9a299edaa2716736
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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