反应详情

A solution of 5-(3-Bromo-5-nitro-phenyl)-1-methyl-1H-tetrazole (2.1 g) in EtOAc (100 ml) was hydrogenated on a H-cube® apparatus at 20° C., room pressure with a flow rate of 1 ml/min using a Raney-Ni cartridge. After reaction completion, the mixture was concentrated in vacuum and triturated with MeOH. The solid was filtered and further triturated and air-dried to give the title compound (290 mg). Rt 1.25 min (method D).

1. customwas hydrogenated on a H-cube® apparatus at 20° C.
2. customAfter reaction completion
3. concentrationthe mixture was concentrated in vacuum
4. customtriturated with MeOH
5. filtrationThe solid was filtered
6. customfurther triturated
7. customair-dried