1,1'-Carbonyldiimidazole → HCID 22632921, compound

HRID 2416792Notes

Reaction equation

HRID 2416792 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[CH3:13][O:14][C:15]1[CH:40]=[CH:39][C:18]([NH:19][C:20]2[CH:36]=[C:35]([F:37])[C:34]([F:38])=[CH:33][C:21]=2[C:22]([NH:24][O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:23])=[CH:17][CH:16]=1>>[CH3:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([N:19]2[C:20]3[C:21](=[CH:33][C:34]([F:38])=[C:35]([F:37])[CH:36]=3)[C:22](=[O:23])[N:24]([O:25][CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:1]2=[O:2])=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 22632938HCID 22632938, compound

Product 1

HCID 22632921HCID 22632921, compoundYield 45.2%

Procedure

Using General Method 3, the reaction of carbonyldiimidazole (6.7 g, 41.6 mmol) and crude 2-(4-methoxy-anilino)-N-benzyloxy-4,5-difluoro-benzamide (Example V, 8.0 g, 20.8 mmol) provided 3.86 g of the title compound as a solid, mp 211-212° C.

Sources & evidence

ORD record
ord-27a9ad37b0404926ae5491cb9182a044
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

Loading…