1,1'-Carbonyldiimidazole → HCID 22632902, compound

HRID 2416796Notes

Reaction equation

HRID 2416796 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[F:13][C:14]1[CH:15]=[C:16]([CH:37]=[CH:38][CH:39]=1)[NH:17][C:18]1[CH:34]=[C:33]([F:35])[C:32]([F:36])=[CH:31][C:19]=1[C:20]([NH:22][O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21]>>[F:13][C:14]1[CH:15]=[C:16]([N:17]2[C:18]3[C:19](=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[C:20](=[O:21])[N:22]([O:23][CH2:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:1]2=[O:2])[CH:37]=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 22632972HCID 22632972, compound

Product 1

HCID 22632902HCID 22632902, compoundYield 31.2%

Procedure

Using General Method 3, the reaction of carbonyldiimidazole (4.7 g, 29 mmol) and crude 2-(3-fluoro-anilino)-N-benzyloxy-4,5-difluoro-benzamide (Example Z, 5.4 g, 14.5 mmol) provided 1.8 g of the title compound as a solid, mp 179-181° C.

Sources & evidence

ORD record
ord-9c2cdd2f6f174e839e44df6ff539ce43
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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