Triethylamine → HCID 22633034, compound

HRID 2416817Notes

Reaction equation

HRID 2416817 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[F:21][C:22]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:23]=1[N:30]1[C:39]2[C:34](=[CH:35][C:36]([F:41])=[C:37](F)[CH:38]=2)[C:33](=[O:42])[N:32]([O:43][CH2:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:31]1=[O:51]>>[F:21][C:22]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:23]=1[N:30]1[C:39]2[C:34](=[CH:35][C:36]([F:41])=[C:37]([N:11]3[CH2:12][CH2:13][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:10]3)[CH:38]=2)[C:33](=[O:42])[N:32]([O:43][CH2:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:31]1=[O:51]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 22632946HCID 22632946, compound

Product 1

HCID 22633034HCID 22633034, compoundYield 52.8%

Procedure

Using General Method 4, the reaction of 3-t-butoxycarbonylamino-pyrrolidine (0.231 g, 1.24 mmol), triethylamine (0.178 mL, 1.24 mmol), and 1-(2,4,5-trifluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example H-1, 0.18 g, 0.41 mmol) provided 0.13 g of the title compound as a solid.

Sources & evidence

ORD record
ord-f0eb38bb8f7a4cdcaf86229d6d460e82
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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