Sodium Hydroxide → HCID 22632954, compound

HRID 2416823Notes

Reaction equation

HRID 2416823 reaction equation
[CH:1]1([NH:4][C:5]2[C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][C:8]([F:16])=[C:7]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]3)[N:6]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C1COCC1.O>[CH:1]1([NH:4][C:5]2[C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]([F:16])=[C:7]([N:17]3[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]3)[N:6]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22632896HCID 22632896, compound

Product 1

HCID 22632954HCID 22632954, compoundYield 63.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Example G-2, the reaction of ethyl 2-cyclopropylamino-5-fluoro-6-(4-methylpiperazinyl)-3-pyridinecarboxylate (Example F-2, 0.86 g, 2.67 mmol) with NaOH (1.40 g, 35 mmol) in THF (5 mL) and water (2 mL) provided 0.50 g of the title compound as a foam.

Sources & evidence

ORD record
ord-638299ec91c242439acc6f2924477c93
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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