反应详情

温度

80 °C

A solution of 2-amino-N-benzyloxy-3,4,5,6-tetrafluoro-benzamide (Example V-3, 1.72 g, 5.47 mmol) in 1,4-dioxane (50 mL) was reacted with a 20% solution of phosgene (4.25 mL, 8.00 mmol) in toluene and heated to 80° C. in a sealed tube for 18 hours. The mixture was then cooled, diluted with ethyl acetate, and washed with saturated aqueous NaHCO3. The organic layer was dried with magnesium sulfate and concentrated. The residue was triturated with diethyl ether and filtered to provide 0.95 g of the title compound as a solid.

1. temperatureThe mixture was then cooled
2. washwashed with saturated aqueous NaHCO3
3. dry with materialThe organic layer was dried with magnesium sulfate
4. concentrationconcentrated
5. customThe residue was triturated with diethyl ether
6. filtrationfiltered