HCID 22632898, compound → HCID 22632881, compound

HRID 2416888Notes

Reaction equation

HRID 2416888 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:24])=[C:16]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[CH:17]=3)[C:12](=[O:25])[N:11]([O:26]CC3C=CC=CC=3)[C:10]2=[O:34])[CH:6]=[CH:7][CH:8]=1>[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:24])=[C:16]([N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[CH:17]=3)[C:12](=[O:25])[N:11]([OH:26])[C:10]2=[O:34])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 22632898HCID 22632898, compound

Product 1

HCID 22632881HCID 22632881, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.04 g) with 1-(3-methoxyphenyl)-6-fluoro-3-benzyloxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example T-1, 0.12 g, 0.26 mmol) afforded 0.09 g of the title compound as a solid, mp 216-218° C.

Sources & evidence

ORD record
ord-c8360e2abea5411fafa9d58c25edc13c
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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