反应详情

To a solution of the product obtained in Step H (0.2 g) in THF (10 ml) at 0° C. there is added, in portions, lithium aluminium hydride. After stiffing for 3 hours at ambient temperature, the reaction mixture is hydrolysed at 0° C. with aq. NaOH solution and water. After filtration, the filtrate is evaporated to dryness and the residue obtained is purified on silica gel (SiO2: gradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH) to yield the title product, which is used directly in the next Step.

1. filtrationAfter filtration
2. customthe filtrate is evaporated to dryness
3. customthe residue obtained
4. customis purified on silica gel (SiO2
5. additiongradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH)