HCID 20741403, compound → HCID 12990810, compound

HRID 2417246Notes

Reaction equation

HRID 2417246 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C@@H:16]1[CH2:20][CH2:19][N:18]([C@@H](C2C=CC=CC=2)C)[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[C].[Pd].C(O)C>[C:1]([O:5][C:6]([NH:8][CH:9]([C@@H:16]1[CH2:20][CH2:19][NH:18][CH2:17]1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 20741403HCID 20741403, compound

Product 1

HCID 12990810HCID 12990810, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

Ethanol (20 ml) solution of 3-(R)-[1-tert-butoxycarbonylamino-1-phenylmethyl]-1-[1-(R)-phenylethyl]pyrrolidine [F1] (495 mg, 1.30mmol) was mixed with 10% palladium-carbon catalyst (53.8% moisture, 500 mg), and 4 hours of catalytic hydrogenation was carried out under atmospheric pressure while heating at an outer temperature of 50° C. The reaction solution was filtered and the solvent was evaporated under a reduced pressure to obtain 359 mg (quantitative) of crude product of the title compound as colorless crystals.

Workup

  1. filtrationThe reaction solution was filtered
  2. customthe solvent was evaporated under a reduced pressure

Sources & evidence

ORD record
ord-8dcfc0c72afe4d59a05e6e6db1053de7
Source dataset
uspto-grants-2004_11
Patent number
US06825353B2

Reaction notes

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