HCID 20741403, compound → HCID 12990810, compound

Participants

Reaction Conditions

Reaction Steps

Ethanol (20 ml) solution of 3-(R)-[1-tert-butoxycarbonylamino-1-phenylmethyl]-1-[1-(R)-phenylethyl]pyrrolidine [F1] (495 mg, 1.30mmol) was mixed with 10% palladium-carbon catalyst (53.8% moisture, 500 mg), and 4 hours of catalytic hydrogenation was carried out under atmospheric pressure while heating at an outer temperature of 50° C. The reaction solution was filtered and the solvent was evaporated under a reduced pressure to obtain 359 mg (quantitative) of crude product of the title compound as colorless crystals.

Provenance & Evidence