4-Mercaptophenol → Ethyl(3-chlorophenyl)[(4-hydroxyphenyl)sulfanyl]acetate

HRID 2417271Notes

Reaction equation

Br[CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[SH:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1)[S:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1)[CH3:7]

Participants

Reactant 2

HCID 2401474-Mercaptophenol

HCID 12717576Ethyl 2-Bromo-2-(3-chlorophenyl)acetate

Product 1

HCID 131724674Ethyl(3-chlorophenyl)[(4-hydroxyphenyl)sulfanyl]acetateYield 82%

Procedure

Ethyl(3-chlorophenyl)[(4-hydroxyphenyl)sulfanyl]acetate was prepared according to the general method as outlined in example 1 (step 1), starting from ethyl bromo(3-chlorophenyl)acetate (6.16 g, 16.5 mmol) and 4-mercaptophenol (2.08 g, 16.5 mmol); 4.36 g clear oil. Yield 82%; MS: 321 (M−H)−

Sources & evidence

ORD record: ord-834dc981e2f34c8d860f0dfacb6cff05
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06825354B2

Reaction notes

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