Acetyl chloride → HCID 11750539, compound

HRID 2417285Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:26])[CH:5]([S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]#[C:24][CH3:25])=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:2].[C:27](Cl)(=[O:29])[CH3:28]>>[CH2:1]([O:3][C:4](=[O:26])[CH:5]([CH:6]1[CH2:7][CH2:8][N:9]([C:27](=[O:29])[CH3:28])[CH2:10][CH2:11]1)[S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]#[C:24][CH3:25])=[CH:17][CH:16]=1)(=[O:13])=[O:14])[CH3:2]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 11360973HCID 11360973, compound

Product 1

HCID 11750539HCID 11750539, compoundYield 89%

Procedure

Ethyl(1-acetyl-4-piperidinyl){[4-(2-butynyloxy)phenyl]sulfonyl}acetate was prepared according to the general method as outlined in example 116 (step 1), starting from ethyl{[4-(2-butynyloxy)phenyl]sulfonyl}(4-piperidinyl)acetate (1.5 g, 3.61 mmol) and acetyl chloride (0.26 ml, 3.61 mmol); yellow oil (1.35 g). Yield 89%; MS: 422 (M+H)+

Sources & evidence

ORD record: ord-9509ea3e4fce4760bfc5d1bea177df54
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06825354B2

Reaction notes

Loading…