HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3,5-Dimethyl-1H-pyrrole-2-carbaldehyde | HCID 270465 | — |
| Reactant | 5-(2-Oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one | HCID 66636156 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one | HCID 66636332 | — |
Reaction Steps
A solution of 5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one (4.3 mmoles), 3,5-dimethyl-1H-pyrrole-2-carbaldehyde (5.17 mmoles) and piperidine (3 mmoles) in ethanol (30 ml) is heated at reflux for 24 hours. The solid formed is filtered off, washed with ethanol, with water and then with ethanol and dried in vacuo to yield the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653073B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-aec92611ce764018841a7c927e0ad948 |
| Source note | uspto-grants-2014_02 |