4-Aminophenol → HCID 22634650, compound

HRID 2417343Notes

Reaction equation

[CH3:1][C:2]1[C:3]([C:16]2[CH:17]=[C:18](C=CC(Cl)=O)[CH:19]=[CH:20][CH:21]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.[OH:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1>>[OH:27][C:28]1[CH:34]=[CH:33][C:31]([NH:32][C:28](=[O:27])[C:29]([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([C:3]3[C:2]([CH3:1])=[CH:11][C:10]4[C:9]([CH3:12])([CH3:13])[CH2:8][CH2:7][C:6]([CH3:14])([CH3:15])[C:5]=4[CH:4]=3)[CH:17]=2)=[CH2:30])=[CH:30][CH:29]=1

Participants

Reactant 2

HCID 4034-Aminophenol

HCID 53728690HCID 53728690, compound

Product 1

HCID 22634650HCID 22634650, compound

Procedure

In similar manner to Example 27(a), by reaction of 1.2 g (3.2 mmol) of 3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)phenylacryloyl chloride with 349 mg (3.2 mmol) of 4-hydroxyaniline, 810 mg of (57%) of N-(4-hydroxyphenyl)-3-(3,5,5,8,8-pentamethyl-5,6,7,6-tetrahydro-2-naphthyl)phenylacrylamide are obtained, with a melting point of 240-1° C.

Workup

customare obtained, with a melting point of 240-1° C.

Sources & evidence

ORD record: ord-6d2cef16c8294119ab13787109503af9
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06825360B1

Reaction notes

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