HCID 22117972, compound → HCID 85801419, compound

HRID 2417356Notes

Reaction equation

HRID 2417356 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([C:13]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:14]=2[CH:15]=[C:16]([CH3:22])[CH2:17]3)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[Li:25]CCCC>CCCCC>[F:1][C:2]([F:23])([F:24])[C:3]1[CH:4]=[C:5]([C:13]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:14]=2[CH:15]=[C:16]([CH3:22])[CH-:17]3)[CH:6]=[C:7]([C:9]([F:11])([F:12])[F:10])[CH:8]=1.[Li+:25]

Participants

4

Reactant 2

HCID 22117972HCID 22117972, compoundHCID 178418339Butyllithium

Product 1

HCID 85801419HCID 85801419, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

4-[3′,5′-bis(trifluoromethyl) phenyl]-2-methylindene (2.2 g, 675 mmol) was dissolved in 50 mL of pentane. To this solution was added 2.6 mL of n-BuLi (2.5M in hexane) and the reaction was allowed to stir 4 hours at room temperature. A yellow-white solid precipitated from solution and was collected by frit filtration and washed with additional pentane. Yield was 1.6 g (73%).

Workup

  1. customA yellow-white solid precipitated from solution
  2. filtrationwas collected by frit filtration
  3. washwashed with additional pentane

Sources & evidence

ORD record
ord-3e229069ac1f4710966a62340cdd8c12
Source dataset
uspto-grants-2004_11
Patent number
US06825372B2

Reaction notes

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