反应详情

To a solution of 1.6 g (10 mmol) of 6,7,8,9-Tetrahydro-5H-benzocyclohepten-5-ol in 75 mL of benzene was added p-toluene sulfonic acid (19 mg, 0.1 mmol). The mixture was refluxed overnight using Dean-Stark equipment. After removal of the solvent, the residue was repartitioned between ethyl acetate and water. The organic layers was washed with saturated sodium bicarbonate solution, water and brine and dried over sodium sulfate. Removal of the solvent gave 1.3 g (88%) of 6,7-Dihydro-5H-benzocycloheptene(compound 23,scheme 11).

1. temperatureThe mixture was refluxed overnight
2. customAfter removal of the solvent
3. washThe organic layers was washed with saturated sodium bicarbonate solution, water and brine
4. dry with materialdried over sodium sulfate
5. customRemoval of the solvent