Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Indene | HCID 7219 | — |
| Reactant | Benzenecarboximidamide, 4-amino-, hydrochloride (1:1) | HCID 122765 | — |
| Reactant | Indium(III) trifluoromethanesulfonate | HCID 2734680 | — |
| Reactant | HCID 88006991 | HCID 88006991 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69892862 | HCID 69892862 | — |
Reaction Steps
4-amino-benzamidine mono HCl salt (120 mg, 0.7 mmole) was suspended in acetonitrile (4 mL). The suspension was treated with 4-(5-Benzyloxy-2-formyl-4-methoxy-phenoxy)-benzoic acid methyl ester (274 mg, 0.7 mmole) and indene (162 mg, 1.4 mmole). Indium triflate (79 mg, 0.14 mmole) was added and the reaction was heated at 75° C. for 18 hours to give 4-[5-Benzyloxy-2-(2-carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-4-methoxy-phenoxy]-benzoic acid methyl ester which was purified by column chromatography (10%methanol in ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06825208B2 |
|---|
| Source dataset | uspto-grants-2004_11 |
|---|
| ORD ID | ord-7acb104fe1a7478198d7d2f668da3ad5 |
|---|
| Source note | uspto-grants-2004_11 |
|---|
