反应详情

温度

75 °C

4-amino-benzamidine mono HCl salt (120 mg, 0.7 mmole) was suspended in acetonitrile (4 mL). The suspension was treated with 4-(5-Benzyloxy-2-formyl-4-methoxy-phenoxy)-benzoic acid methyl ester (274 mg, 0.7 mmole) and indene (162 mg, 1.4 mmole). Indium triflate (79 mg, 0.14 mmole) was added and the reaction was heated at 75° C. for 18 hours to give 4-[5-Benzyloxy-2-(2-carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-4-methoxy-phenoxy]-benzoic acid methyl ester which was purified by column chromatography (10%methanol in ethyl acetate).