HCID 69892862, compound → 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester

HRID 2417390Notes

Reaction equation

HRID 2417390 reaction equation
[CH3:1][O:2][C:3](=[O:47])[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[C:15]([O:17]CC3C=CC=CC=3)[C:14]([O:25][CH3:26])=[CH:13][C:12]=2[CH:27]2[CH:36]3[CH2:37][C:38]4[C:43]([CH:35]3[C:34]3[C:29](=[CH:30][CH:31]=[C:32]([C:44](=[NH:46])[NH2:45])[CH:33]=3)[NH:28]2)=[CH:42][CH:41]=[CH:40][CH:39]=4)=[CH:6][CH:5]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:47])[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[C:15]([OH:17])[C:14]([O:25][CH3:26])=[CH:13][C:12]=2[CH:27]2[CH:36]3[CH2:37][C:38]4[C:43]([CH:35]3[C:34]3[C:29](=[CH:30][CH:31]=[C:32]([C:44](=[NH:45])[NH2:46])[CH:33]=3)[NH:28]2)=[CH:42][CH:41]=[CH:40][CH:39]=4)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 69892862HCID 69892862, compound

Product 1

HCID 698950294-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-[5-Benzyloxy-2-(2-carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-4-methoxy-phenoxy]-benzoic acid methyl ester (63 mg, 0.1 mmol) in 2 mL of MeOH was hydrogenated overnight using 10%Pd—C (20 mg) to give 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester that was used without further purification.

Sources & evidence

ORD record
ord-bad5613202ea469db016a08ffe7ee3fc
Source dataset
uspto-grants-2004_11
Patent number
US06825208B2

Reaction notes

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