Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Indene | HCID 7219 | — |
| Reactant | Indium(III) trifluoromethanesulfonate | HCID 2734680 | — |
| Reactant | tert-butyl N-[(4-aminophenyl)methyl]carbamate | HCID 2756041 | — |
| Reactant | HCID 22633232 | HCID 22633232 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 22633173 | HCID 22633173 | — |
Reaction Steps
(4-Amino-benzyl)-carbamic acid tert-butyl ester (200 mg, 0.9 mmole) was dissolved in acetonitrile (5 mL). The solution was treated with 4-Hydroxy-5-methoxy-2-(2-methoxy-phenoxy)-benzaldehyde (250 mg, 0.9 mmole) and indene (130 mg, 1.1 mmole). Indium triflate (600 mg, 1.1 mmole) was added and the reaction was heated at 70° C. for 18 hours to give 4-(2-Aminomethyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-2-methoxy-5-(2-methoxy-phenoxy)-phenol which was then purified using reverse phase HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06825208B2 |
|---|
| Source dataset | uspto-grants-2004_11 |
|---|
| ORD ID | ord-abc99f78d9ee4b5eace8553df3305c01 |
|---|
| Source note | uspto-grants-2004_11 |
|---|
