反应详情

温度

70 °C

(4-Amino-benzyl)-carbamic acid tert-butyl ester (200 mg, 0.9 mmole) was dissolved in acetonitrile (5 mL). The solution was treated with 4-Hydroxy-5-methoxy-2-(2-methoxy-phenoxy)-benzaldehyde (250 mg, 0.9 mmole) and indene (130 mg, 1.1 mmole). Indium triflate (600 mg, 1.1 mmole) was added and the reaction was heated at 70° C. for 18 hours to give 4-(2-Aminomethyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-2-methoxy-5-(2-methoxy-phenoxy)-phenol which was then purified using reverse phase HPLC.