Ethanolamine → 2-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

HRID 241745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 241745
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[NH2:13][CH2:14][CH2:15][OH:16]>>[N+:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][NH:13][CH2:14][CH2:15][OH:16])=[CH:5][CH:6]=1)([O-:12])=[O:11]

Komponenten

3

Edukt 2

HCID 700EthanolamineHCID 792664-Nitrophenethyl bromide

Produkt 1

HCID 227227442-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A mixture of 1-(2-bromo-ethyl)-4-nitro-benzene (86.9 mmoles) and 2-amino-ethanol (869 mmoles) is heated at 150° C. under microwave activation for 10 minutes. The reaction mixture is evaporated to dryness and the residue obtained is purified on silica gel (SiO2; gradient DCM/MeOH) to yield the title product, which is used directly in the next Step.

Aufarbeitung

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue obtained
  3. customis purified on silica gel (SiO2; gradient DCM/MeOH)

Quellen und Nachweise

ORD-Eintrag
ord-a45a2c6abdd64f37bd40b46e080c119b
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653073B2

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