Triethylamine → HCID 86589871, compound

Participants

Reaction Steps

1.15 g (4.2 mmol) of ethyl (5-chloro-2-nitrobenzyl)aminoacetate was dissolved in 20 ml of dichloromethane. 0.64 ml (5.1 mmol) of 4-chlorobenzoyl chloride and 0.88 ml (6.3 mmol) of triethylamine were added to the obtained solution, and they were stirred at room temperature for 2 hours. After the treatment with dichloromethane as the extracting solvent by an ordinary method, the obtained crude product was dissolved in 20 ml of ethyl acetate. 120 mg of 10% palladium/carbon was added to the obtained solution and they were stirred in the presence of hydrogen at room temperature for 4 hours. The reaction solution was filtered through Celite. The solvent was evaporated and the obtained crude product was purified by the silica gel column chromatography to obtain the title compound.

Provenance & Evidence