反应详情

1.15 g (4.2 mmol) of ethyl (5-chloro-2-nitrobenzyl)aminoacetate was dissolved in 20 ml of dichloromethane. 0.64 ml (5.1 mmol) of 4-chlorobenzoyl chloride and 0.88 ml (6.3 mmol) of triethylamine were added to the obtained solution, and they were stirred at room temperature for 2 hours. After the treatment with dichloromethane as the extracting solvent by an ordinary method, the obtained crude product was dissolved in 20 ml of ethyl acetate. 120 mg of 10% palladium/carbon was added to the obtained solution and they were stirred in the presence of hydrogen at room temperature for 4 hours. The reaction solution was filtered through Celite. The solvent was evaporated and the obtained crude product was purified by the silica gel column chromatography to obtain the title compound.

1. filtrationThe reaction solution was filtered through Celite
2. customThe solvent was evaporated
3. customthe obtained crude product
4. customwas purified by the silica gel column chromatography