Triethylamine → HCID 22632535, compound

HRID 2417487Notes

Reaction equation

HRID 2417487 reaction equation
[Cl:1][C:2]1[CH:40]=[CH:39][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:18][C:12]=3[N:11]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]([N:33]4[CH2:37][CH:36]=[CH:35][CH2:34]4)=[O:32])=[CH:27][CH:26]=3)[C:10](=[O:38])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[CH2:41](N(CC)CC)[CH3:42]>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][C:21]([O:23][CH2:41][CH3:42])=[O:22])=[CH:18][C:12]=3[N:11]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]([N:33]4[CH2:37][CH:36]=[CH:35][CH2:34]4)=[O:32])=[CH:27][CH:26]=3)[C:10](=[O:38])[CH2:9]2)=[O:7])=[CH:39][CH:40]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 22632458HCID 22632458, compound

Product 1

HCID 22632535HCID 22632535, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10 mg (0.018 mmol) of 3[4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]-diazepin-8-propionic acid was dissolved in 2 ml of dichloro-methane. 4 mg (0.02 1 mmol) of 2-chloro-1,3-dimethylimidazonium chloride and 0.005 nil (0.036 mmol) of triethylamine were added to the obtained solution, and they were stirred overnight. The solvent was evaporated and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Workup

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

Sources & evidence

ORD record
ord-bf0a1d823a4e4745912e36ac3acd489d
Source dataset
uspto-grants-2004_11
Patent number
US06825191B2

Reaction notes

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