HRID2417491

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID76113

Silane, bromotrimethyl-

C3H9BrSi

结构：CCOP(=O)(CCc1ccc2c(c1)N(Cc1ccc(C(=O)N3CC=CC3)cc1)C(=O)CN(C(=O)c1ccc(Cl)cc1)C2)OCC

HCID60123508

未命名化合物

PRODUCTS

生成物

结构：O=C(c1ccc(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccc(CCP(=O)(O)O)cc32)cc1)N1CC=CC1

HCID22632357

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

40 mg (0.051 mmol) of diethyl [2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)-benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)ethyl]phosphonate was dissolved in 10 ml of acetonitrile. 0.15 ml of trimethylsilyl bromide was added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

WORKUP

后处理

customThe solvent was evaporated
customthe obtained crude product
additionwas treated in the same manner as in step 3 in Example 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6c0a6a58ffb34b6eab5d1a4bf27316c5
来源数据集: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06825191B2
来源说明: uspto-grants-2004_11

反应 SMILES

[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][P:21](=[O:28])([O:25]CC)[O:22]CC)=[CH:18][C:12]=3[N:11]([CH2:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([N:38]4[CH2:42][CH:41]=[CH:40][CH2:39]4)=[O:37])=[CH:32][CH:31]=3)[C:10](=[O:43])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.C[Si](Br)(C)C>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][P:21](=[O:22])([OH:25])[OH:28])=[CH:18][C:12]=3[N:11]([CH2:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([N:38]4[CH2:42][CH:41]=[CH:40][CH2:39]4)=[O:37])=[CH:32][CH:31]=3)[C:10](=[O:43])[CH2:9]2)=[O:7])=[CH:44][CH:45]=1