Bromotrimethylsilane → [2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo-[e][1,4]-diazepin-8-yl)ethyl]phosphonic Acid

Participants

Reaction Steps

40 mg (0.051 mmol) of diethyl [2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)-benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)ethyl]phosphonate was dissolved in 10 ml of acetonitrile. 0.15 ml of trimethylsilyl bromide was added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Provenance & Evidence