Tributyltin azide → HCID 178519602, compound

HRID 2417546Notes

Reaction equation

HRID 2417546 reaction equation
[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([C:19]#[N:20])=[CH:18][C:12]=3[N:11]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)=[O:29])=[CH:24][CH:23]=3)[C:10](=[O:35])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.C([Sn]([N:51]=[N+:52]=[N-:53])(CCCC)CCCC)CCC>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([C:19]4[NH:53][N:52]=[N:51][N:20]=4)=[CH:18][C:12]=3[N:11]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([N:30]4[CH2:31][CH2:32][CH2:33][CH2:34]4)=[O:29])=[CH:24][CH:23]=3)[C:10](=[O:35])[CH2:9]2)=[O:7])=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 4984872Tributyltin azideHCID 22632325HCID 22632325, compound

Product 1

HCID 178519602HCID 178519602, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

30 mg (0.059 mmol) of 4-(4-chlorobenzoyl)-8-cyano-1-[4-(pyrrolidinylcarbonyl)benzyl]-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-on was dissolved in 2 ml of toluene. 0.032 ml (0.11 mmol) of tributyltin azide was added to the obtained solution, and they were stirred at 120° C. for 6 hours. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the solvent was evaporated and the obtained crude product was treated in the same manner as in Step 3 in Example 1 to obtain the title compound.

Workup

  1. customAfter the treatment with ethyl acetate as the extracting solvent by an ordinary method, the solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in Step 3 in Example 1

Sources & evidence

ORD record
ord-eb21b4a00e32456bb7a4cef7edca924c
Source dataset
uspto-grants-2004_11
Patent number
US06825191B2

Reaction notes

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