Methyl iodide → HCID 22632612, compound

Participants

Reaction Steps

11 mg (0.017 mmol) of ethyl 4-(4-chlorobenzoyl)-2-oxo-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-8-carboxylate trifluoroacetate obtained in Example 204 was dissolved in 3 ml of acetonitrile. 10 mg (0.08 mmol) of potassium carbonate and 0.05 ml (0.32 1) of methyl iodide were added to the obtained solution, and they were stirred at room temperature for 5 hours. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Provenance & Evidence