Methyl iodide → HCID 22632612, compound

HRID 2417552Notes

Reaction equation

HRID 2417552 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:46]=[CH:45][C:12]([C:13]([N:15]2[CH2:21][C:20]3[CH:22]=[CH:23][C:24]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:25][C:19]=3[N:18]([CH2:31][C:32]3[CH:37]=[CH:36][C:35]([C:38]4[N:39]([CH3:43])[CH2:40][CH2:41][N:42]=4)=[CH:34][CH:33]=3)[C:17](=[O:44])[CH2:16]2)=[O:14])=[CH:11][CH:10]=1.[C:47](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[Cl:8][C:9]1[CH:46]=[CH:45][C:12]([C:13]([N:15]2[CH2:21][C:20]3[CH:22]=[CH:23][C:24]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:25][C:19]=3[N:18]([CH2:31][C:32]3[CH:37]=[CH:36][C:35]([C:38]4[N:42]([CH3:47])[CH2:41][CH2:40][N+:39]=4[CH3:43])=[CH:34][CH:33]=3)[C:17](=[O:44])[CH2:16]2)=[O:14])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 22632690HCID 22632690, compound

Product 1

HCID 22632612HCID 22632612, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

11 mg (0.017 mmol) of ethyl 4-(4-chlorobenzoyl)-2-oxo-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-8-carboxylate trifluoroacetate obtained in Example 204 was dissolved in 3 ml of acetonitrile. 10 mg (0.08 mmol) of potassium carbonate and 0.05 ml (0.32 1) of methyl iodide were added to the obtained solution, and they were stirred at room temperature for 5 hours. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Workup

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

Sources & evidence

ORD record
ord-7d207ac61cb548f3bee1b628de156b03
Source dataset
uspto-grants-2004_11
Patent number
US06825191B2

Reaction notes

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